Examining the Influence of Component Outcomes on the Composite at the Design Stage

Abstract

While the literature simultaneously promotes and condemns composite endpoints, they are often used as the primary end point in clinical trials. The selection of the individual components to form the composite may be arbitrary, and the various algorithms suggested for combining component outcomes differ in their attempt to maximize clinical meaning while retaining statistical power. Thus, they lead to differential weighting of the component outcomes. We introduce the concept of “influence” for evaluating the extent to which individual component outcomes may be expressed or suppressed in the overall composite

Publication
Circulation: Cardiovascular Quality and Outcomes

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