Frailty modelling

Frailty modelling for multitype recurrent events in clinical trials

Recurrent event outcomes are ubiquitous among clinical trial data which encourages a conventional approach to analysis. Yet a common feature of these data has received less attention, that is, survival times often comprise multiple types of events …

Multitype Events and the Analysis of Heart Failure Readmissions: Illustration of a New Modeling Approach and Comparison With Familiar Composite End Points

Heart failure–related hospital readmissions and mortality are often outcomes in clinical trials. Patients may experience multiple hospital readmissions over time with mortality acting as a dependent terminal event. Univariate composite end points are …